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Considering Recovery of Mitochondrial Function Part 2: Reactive Oxygen Species Production by Senescent Cells

武本 重毅

There are many reports that the production of reactive oxygen species (ROS) from mitochondria is increased in aged animals.

 

Reactive oxygen species have been emphasized as a cause of adult diseases such as “aging“, “arteriosclerosis“, and “cancer“.

 

Such a pathology may be related to the risk factors for severe disease in COVID-19 infection and the increase in the number of elderly deaths.

 

Reactive oxygen species produced by mitochondria also damage mitochondria themselves.

Damaged mitochondria are thought to produce more reactive oxygen species, which in turn aggravate the damage, forming a vicious cycle.

 

In this way, mitochondria have received the most attention as a source of reactive oxygen species, but reactive oxygen species (hydrogen peroxide, superoxide radicals) are also generated as main products or by-products in various enzymatic reactions within cells.

Hydrogen gas inhalation therapy decomposes the reactive oxygen species, and NMN (nicotinamide mononucleotide) therapy repairs mitochondria and restores their function. Both are aging treatments that our clinic specializes in.

Author:

武本 重毅

聚楽内科クリニックの院長、医学博士。