Director's blog

Summary of recent NMN human clinical trials (4)

武本 重毅


At our clinic, we began to hear from patients who continue to take NMN (nicotinamide mononucleotide) supplements that “blood sugar levels have decreased” and “HbA1c levels have decreased.”

This time, we will introduce the results of a clinical trial on diabetes.


Moreover, this research has become the “excellent paper on the world’s first NMN clinical trial” in humans, which has been long-awaited over the past few years.


Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Science. 2021;372(6547):1224-1229.


Research by Associate Professor Mihoko Yoshino, Associate Professor Jun Yoshino, Professor Samuel Klein, and collaborator Professor Shinichiro Imai at the University of Washington School of Medicine, USA, was published in the prestigious medical journal Science in 2021.

 About ten years ago, Associate Professor Jun Yoshino and Professor Shinichiro Imai demonstrated the effects of NMN administration on diabetic mice.

In obese type 2 diabetes, restoration of NAD+ improved glucose tolerance, increased hepatic insulin sensitivity, and restored gene expression related to oxidative stress, inflammatory response, and circadian clock.

And in age-related type 2 diabetes, in addition to glucose tolerance, dyslipidemia was also improved.

In this clinical trial, 25 pre-diabetic (pre-diabetic), obese, postmenopausal women aged 55-75 years were randomized into two groups, 13 receiving 250mg of NMN per day, 12 People took a placebo orally for 10 weeks.

As a result, in the skeletal muscles of the NMN intake group, the insulin sensitivity that lowers the blood sugar level increased by an average of 25%, and the glucose uptake function, which is decreased in type 2 diabetes and those at risk of developing it, improved.

The average 25% increase in insulin sensitivity is comparable to the improvement that occurs when you lose 10% of your weight or take the antidiabetic drug troglitazone for 12 weeks.


Furthermore, in the NMN intake group, the concentration of NAD in blood cells, which decreases with age, increases.

It has also been confirmed that the expression of genes that promote muscle reconstruction has increased.

It was unknown even in mouse studies that NMN enhances muscle remodeling function.


In this way, the effects of NMN on humans have become clear.


武本 重毅